Picolinamides with one, two and three alkoxy chain(s), named V1, V2, and V3, were synthesized and their gelation properties, together with the ion response of their organogels were tested. The microstructure and gelation force of the gels from the three compounds were checked by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), ultra-violet-visible spectroscopy (UV) and 1H nuclear magnetic resonance (1H NMR). Though the number of alkoxy chain of the three picolinamides is different, the morphologies of the checked organogels from them are all fibrous and they have clear ribbonlike 3D networks. What is more, they all have lamellar structure. It is found that hydrogen bonding, π-π interaction, and van der Waals interaction are the driving force of gelation. The organogels from V1, V2, and V3 can respond to the stimuli of both F-and Cu2+. Their reversible gel-sol transitions can be induced by heating and cooling, adding and removing F-, reducing Cu2+ and oxidizing Cu+, coordinating Cu2+ and releasing Cu2+, respectively. The organogels are efficient multiple responding ones.