Tetrahydrofuran-3-formic acid and its derivatives, tetrahydrofuran-3-formamide and tetrahydrofuran-3-methonitrile are not only an important intermediate in pesticides and pharmaceuticals, such as palladium chloride as the catalyst, three phenyl phosphine as the ligand, p-toluene sulfonic acid as the promoter, and the hydramine carbonyl of aromatic amine and carbon monoxide through 2,5-dihytrofuran. A series of tetrahydrofuran -3- formamide compounds were synthesized by chemical reaction. The products were characterized by IR, 1HNMR, 13CNMR and HRMS. The adaptability of different aromatic amine substrates was investigated. When the substituents of aniline were alkyl, halogen, methoxy and nitro, the -3- formamide derivatives of tetrahydrofuran were obtained, and the yield was 54.3%~93.2%.