Vidarabine is well known anti-herpes andanti-herpes zoster virus drugs. It’s also the main raw material for the synthesis of downstream products such as vidarabine monophosphate and fludarabine,which are used as antideoxyribonucleic acid virus drug and B-chronic lymphocytic leukemia(B-CLL) powerful drug. So developing the synthesis of vidarabine has wide foreground on market. Vidarabinewas sffectivelysynthesized through five steps including 8-bromo, hydroxyl-sulfonylation, hydroxyl-acetylationas well as configuration inversions and dehydrazination by “one pot, two steps” methods, stating with adenosine, which can be obtained cheaply and conveniently. This method using water as reaction solvent, has some advantage such as simple craftwork, operate safely, less discharge of the three wastesand aconomic, andwith potential development in industrial production.