N,N'-bis-(4,6-dichloro-[1,3,5]-triazin-2-yl)-2,6-diaminohexanic acid(DTDHA for short) have been synthesized by reacting cyanuric chloride(TCT) with lysine under water-mediated conditions. The orthogonal test was carried out on the three factors of molar ratio of reaction raw material, type of acid-binding agent and reaction time, and the suitable reaction conditions were raw material molar ratio n (cyanuric chloride): n (lysine) = 3: 1, KOH as acid binding agent, the reaction time 6h, the yield was 91%. The product was applied to the tanning of raw hides. The shrinkage temperature of the tanning leather was used as the inspection index. The single factor test method was used to optimize the technical conditions of the tanning process. The results showed that the optimum tanning process conditions were as follows: tanning agent dosage 20%, temperature rising from 25°C, stepwise control rising by 15°C every 2 hours, finally reaching to 55°C, total tanning for 8 hours, Under these conditions, the shrinkage temperature of the crust leather is 85.6℃. The synthetic product has a good tanning effect and belongs to a new type of organic synthesis tanning agent.