A CuS/grapheneoxide nano-composite was prepared by using Cu(Ac)2, Na2S and graphene oxide (GO) as main raw materials under hydrothermal condition in present of cetyl trimethyl ammonium bromide(CTMAB), with deionized water as solvent. The sample was characterized by XRD，FT-IR，XPS，SEM and TEM. Eventually, the nanoparticles consisting of 10~20 nm CuS in situ grow on GO. The photocatalytic property of title nano-composite is investigated. The degradation ratio of tetracycline (TC) and rhodamine B (Rh-B) reach 63% and 85% after 120 min (under visible light). The result suggests that the CuS/GO nanocomposite exhibits excellent photocatalytic activity and potential application in the degradation of organic of TC and Rh-B in the pollute water. A linear relation of -ln(C/C0) vs. reaction time was obtained, suggesting that the reaction can be considered as a pseudo-first-order reaction.