The banana microcrystalline cellulose was prepared by the banana fiber, and the esoporous materials were prepared by the mecobalamin, banana microcrystalline cellulose and PLGA. The esoporous materi-als were characterized by SEM, specific surface area and pore size analysis (BET), Thermogravimetric mass spectrometry (TG-MS) and FT-IR. The drug load content, encapsulation efficiency, and in vitro re-lease rate of mesoporous materials loading mecobalamin were studied by the UV spectrophotometry. FT-IR spectrum analysis showed that the main component of microcrystalline cellulose was cellulose. The BET results showed that the average pore diameter [4V(pore volume)/A(surface area)] of banana micro-crystalline cellulose/PLGA mesoporous materials loading mecobalamin was 17.89nm. TG-MS results showed that the decomposition temperature of the materials were about 300℃. The results indicated that the materials had great control release ability, the drug release following zero-order release kinetics.