The nano-zinc oxide was used as the template and the phenolic resin was used as the carbon source. The mesoporous carbon was prepared by a hard template method and used as support for the preparation of Pt-based catalysts. BET, SEM, ICP, TEM were used to characterize the mesoporous carbon and its supported Pt catalysts. The results show that surface area and pore structure of mesoporous carbon can be effectively controlled by varying the size of the nano-zinc oxide particles. The Pt/MC catalytic performance for the antioxidant 7PPD synthesis reaction was studied. Compared with the conventional Pt/AC catalyst, the conversion of p-ADPA reached to 100% from 97.5% and the selectivity of 7PPD reached 99.5% from 94.5% and the stability of the catalysts were significantly improved. The catalysts used ten times were characterized by CO chemisorption, ICP, BET, etc. The results show that the pore structure of the support is an important factor affecting the stability of the catalyst. When the average pore diameter is small, molecules with large molecular sizes such as 7PPD was easy to block the pores. When the average pore diameter is largest, the pore walls are thinner, the catalyst was worn easily during use, and the active components were lost easily.