As an important biomaterial platform molecule, ethanol has become a multi-functional raw material for synthesis of high value-added chemicals. The catalytic performance of various metal halide as catalysts were studied for one-step liquid phase synthesis of 1,1-diethoxyethane (DEE) by oxidation of ethanol. Among them, When RuCl3 was used as catalyst, the catalytic performance was best. Also the influence of the amount of RuCl3, reaction pressure, reaction temperature, reaction time and stirring speed on the performance of oxidation of liquids ethanol to 1,1-diethoxyethane. When the amount of ethanol is 50ml, under the optimized reaction conditions (0.01gRuCl3,2MPa,120℃,3h and 600r/min), the conversion of ethanol reached 38.2% and the selectivity of DEE reached 78.9%.This is because that Ru3+ has good catalytic performance for the oxidation of ethanol to aldehyde, and RuCl3 is a Lewis acid which can promote the condensation of ethanol and acetaldehyde. Last the recycle performance of RuCl3 was investigated, after reused 20 times, RuCl3 catalyst still has good performance.