The composite powders of La0.8Sr0.2MnO3 (LSM) perovskite and MgAl2O4 (MA) spinel, named as LSM/nMA were prepared by deposition-precipitation method. The impact of preparation factors, such as the molar ratio of MA to LSM (n), the aging temperature and calcination temperature of precursors was investigated. The activity of the composite powder was examined in the temperature-programmed micro reactor for catalytic combustion of air diluted methane，and the properties of catalysts were characterized by FTIR, H2-TPR, BET, XRD and SEM. The LSM/4MA catalyst which precursor aged at 10℃ and calcined at 800℃ demonstrated the best activity with T50 489.4℃ and Ea 112.5kJ/mol and excellent sintering resistance with SSA of 81.6m2/g . Afterwards, the wire-mesh honeycomb catalysts were developed by dip-coating sequentially the slurries of MA and LSM/4MA powders. Influences of the loading of MA and LSM/4MA coating were investigated respectively in reactions at GHSV of 40000/h, which gave the best amount in preparation of the wire-mesh honeycombs and the proper coating thickness of MA is around 20?m, the best loading of LSM/4MA is about 2.65mg/cm2.