With complex of p-nitrobenzyl alcohol (p-NBA) and nickel nitrate hexahydrate as template molecule, acrylamide (AM) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent, the Ni nanoparticle molecularly imprinted polymer (Ni-MIP) was prepared by bulk polymerization. The prepared Ni-MIP was characterized by FTIR, UV-Vis, SEM and TEM. Using non-molecularly imprinted polymers of Ni-NIP and NIP as comparison samples, the catalytic activity and selectivity of Ni-MIP for p-NBA were investigated. The results show that in the oxidation reaction of p-NBA with water as solvent and H2O2 as oxidant, the conversion of p-NBA reaches 72% after 1 h with Ni-MIP as catalyst. The conversion rate of p-NBA is 64% with Ni-NIP as catalyst, and NIP has no catalytic effect. The catalytic efficiency of Ni-MIP is 24% for p-NBA structural analogue of o-nitrobenzyl alcohol (o-NBA), which is much lower than that of Ni-NIP. It is indicates that the Ni-MIP catalyst has imprinted cavity matching the substrate molecule p-NBA, which can realize specific recognition catalysis.