N-isopropylacrylamide modified acrylate resin (NAB) and silicone modified acrylate (SBA) emulsion were prepared with reactive emulsifiers. The exterior wall-coating was prepared by applying these two kinds of emulsion as film former, sothiazolinone (MSDS) as antibacterial?agent and calcium carbonate, talcum powder as fillers. Based on the LCST property of NAB resin, the MSDS in this coating can be re-leased with temperature-controlled, which can effectively solve the problems of short mildew-proofing period. This study will provide new strategies for the development of mildew-proofing exterior wall-coating.