A series of inverse уCeO2/CuχCo1-χOδ catalysts were prepared by combinations of co-precipitation method and impregnation method. The influences of the mass ratio of CuO∶Co3O4 and CeO2 loading on the catalytic performance in CO oxidation were investigated using XRD, BET, H2-TPR and XPS techniques. The results revealed that 15%CeO2/Cu0.2Co0.8Oδ catalyst demonstrated the best catalytic performance. It was mainly due to the large specific surface area of 15%CeO2/Cu0.2Co0.8Oδ, more interface, which led to a strong interaction between CeO2 and Cu-Co-O, the more oxygen vacancy, Cu and Co3 on the surface. The reduction temperature decrease of 15%CeO2/Cu0.2Co0.8Oδ enhanced the catalytic activity. Thus, 15% CeO2/Cu0.2Co0.8Oδ catalyst exhibited a higher catalytic activity in the carbon monoxide oxidation with 100% CO conversion at the temperature as low as 75℃ under atmospheric pressure．