As the demand to energy storage devices for renewable energy, portable electronics and electric vehicles increase, lithium-sulfur (Li-S) batteries have attracted much attention for its extremely high energy density. However, the scientific and technical problems such as low electrical conductivity of elemental sulfur and its discharge products, the polysulfides shuttled between the cathode and anode electrodes, large volume change of sulfur particles during charge and discharge, hinder the demonstration of practical Li-S cells. The advanced multifunctional binder system have been proposed and verified to retard the shuttle of polysulfides and extend the cycling life of a Li-S cell. In this review, the progress on multifunctional bind-ers for lithium sulfur batteries are summarized, including multifunctional binder inhibiting polysulfide shut-tles, binder with multidimensional bonding stabilizing the entire electrode and binder with low interfacial resistance. New insights into challenge and opportunities of multifunctional binder system are also pro-spected.