Dual-network high strength hydrogel excipients were prepared from agar, acrylamide, tannic acid (TA) and graphene oxide (GO). GO was reduced by TA and reacted with polyhexamethylene guanidinate (PHMG) in TA/rGO microreactor. It was immobilized in the hydrogel skeleton to prepare antimicrobial hydrogel excipients. The properties of the gels were tested by mechanical properties, thermodynamic properties and antibacterial properties. The results showed that the elongation at break of the gel increased by 60%, increase in compressive strength, the internal porosity of the gel was further reduced, and the mechanical properties were improved; When soaked in 2.0% PHMG aqueous solution, the antibacterial rate of E. coli and S. aureus reached above 99.80%; no bacteriostatic circle was formed, indicating that PHMG was immobilized in gel; Hemolysis of erythrocyte (RBC) showed that the gel hemolysis rate was lower than 5%, and the antibacterial hydrogel had good biocompatibility.