In order to study the degree of reconstruction of irregularly shaped bone defect models using 3D printing technology and the effect of 3D printed degradable biomaterials on the repair of vertebral bone defects in three months. Biodegradable biomaterials, polycaprolactone (PCL) were used as the printing ink to print scaffold materials for repair. An irregular three-dimensional spine defect model was constructed using CT data from a randomly chosen patient. An artificial bone scaffold with a height that matches the patient's bone defect was first printed using 3D printing. At the same time, a rabbit spinal defect model was established, and a defect-sized stent was transplanted into the rabbit using 3D printing technology. The defect was removed from the rabbit after 3 months of surgery and sections of the defect area were made for Hematoxylin and Eosin (H&E) staining. The repair indicated that 3D printed bone scaffold has a promising application on the treatment of irregular bone defects formed during spinal surgery.