SBA-15 mesoporous molecular sieve was prepared with the microcrystalline cellulose (MCC) as an auxiliary template, and then Ni/SBA-15-MCC hydrodearomatization catalyst was prepared with SBA-15-MCC mesoporous sieve as a support. The catalyst was characterized with XRD, N2 adsorption-desorption, FTIR, XPS, H2-TPR and SEM. The catalytic performance of the catalyst was evaluated on a fixed bed micro-reactor, with the dodecane solution of naphthalene as the model fuel. The results show of that Ni/SBA-15-MCC had the larger pore diameter and the higher mesopore order than Ni/SBA-15 without MCC. The residual carbon group on the surface of Ni/SBA-15-MCC reduce the interaction between NiO and support. Such changes are beneficial to reduce the diffusion resistance of the reaction, NiO dispersion and reduction and ease the competitive adsorption of between naphthalene and tetrahydronaphthalene, thus the catalytic activity and selectivity were improved. Under the conditions of reaction, pressure 3 MPa, temperature 280 ℃, volume ratio of hydrogen to oil 360 and mass space velocity 2.5 h-1, the naphthalene conversion on Ni/SBA-15-MCC closed to 100%, and the decalin selectivity was 98.8%, compared with Ni/SBA-15, they were increased by 6% and 10% respectively.