Yttria-stabilized zirconia (YSZ) hollow fiber membrane was prepared by a combined phase inversion/sintering method. The effects of YSZ content and sintering temperature on the microstructure and properties of the prepared hollow fiber membrane were investigated. The results show an asymmetric structure of YSZ hollow fiber membrane containing finger-like structure and sponge-like structure. The YSZ content impacted the ratio between finger-like structure and sponge-like structure, and sintering process caused a densification of microstructure. Under the conditions of m(YSZ):m(PSF):m(NMP)=5.0:1:4, sintering temperature of 1200 ℃, the pure water flux was 2.33 m3/(m2·h·MPa) and the bending strength was 134.5 MPa.