The epoxidation of alkene catalyzed by titanium silicalite-1 has the advantages of mild conditions, environmental friendliness, conforming to the concept of green chemistry, and broad application prospects. Herein, the research progress of epoxidation of aliphatic alkenes catalyzed by TS-1 with hydrogen peroxide (H2O2) as oxidant in different media was mainly discussed. It was found that an active intermediate was formed from Ti—OOH(Titanium Oxide Active Center) and solvent through hydrogen bonding promoting the epoxidation of alkenes to epoxide when the epoxidation was performed in protonic solvents such as methanol. Meanwhile, the acid center of TS-1 can also promote side reactions such as ring-opening and polymerization of epoxides. Treatment of TS-1 with appropriate amount of alkaline additives can reduce the amounts of acid sites, inhibit the formation of by-products to improve the selectivity of epoxidation products. On the other hand, the catalytic performance of TS-1 for alkene epoxidation can be improved by modification with acid, alkali, silanization or metal salt. In addition, the deactivation of TS-1 is mainly ascribed to carbon deposition in catalytic run. The activity of the catalyst can be recovered largely by calcination in high temperature, oxidation by hydrogen peroxide in situ or washing with hot solvent. They are forecasted that investigations on the novel synthetic and modifying methods, and the relationship between the regeneration protocol and the activity of TS-1 are the developing trends in this field in the future.