CuMgLa/Al2O3 was prepared from Cu(NO3)2•3H2O by coprecipitation method and characterized by TEM and N2 adsorption-desorption technique. The results showed that CuMgLa/Al2O3 had a mesoporous structure and the particle size of the main active component CuO was about 25 nm. The effects of temperature and catalyst mass concentration on the degradation of quinoline by wet catalytic oxidation were investigated. It was found that under the conditions of mass concentration of quinoline simulated wastewater 1000 mg/L, catalyst mass concentration 0.2 g/L, reaction temperature 240 °C, oxygen partial pressure 0.53 MPa, reaction time 60 min, the removal rate of quinoline could reach about 100.0%, and the removal rate of chemical oxygen demand（COD）could reach 94.8%. The quenching experiments of tert-butanol revealed that ·OH oxidation played a key role in quinoline degradation. The intermediate of quinoline degradation was analyzed by LC-MS and UV-Vis, and the possible degradation path of quinoline was speculated. Meanwhile, under the optimal conditions, COD removal rate of 7000 mg/L mass concentration of simulated coking wastewater could reach 94.6%. The removal rates of COD and NH3-N were 69.6% and 28.0% for the actual coking wastewater with COD and NH3-N mass concentration of 4740 and of 884.2 mg/L.