Phenol-amine chelating resin based on tannin was prepared by the cross-linking reaction of polyethylenimine and chlorinated tannin, where chlorinated tannin was synthesized by the reaction of tannins with thionyl chloride. The phenol-amine chelating resin based on tannin was characterized by FTIR, SEM, EDS and XPS, and the adsorption properties of chelating resin based on tannin for Cr(VI) were evaluated. The adsorption properties of the chelating resin based on tannin were effectively improved owning to the introduction of the amino group into the side chain of tannin molecular structure. The adsorption of Cr(VI) by the chelating resin based on tannin is mainly reduction adsorption, which is mainly adsorbed on the resin in the form of Cr(III). The maximum adsorption capacity of the resin for Cr(VI) was 364.46 mg/g at 318 K and pH 2.0 when initial concentration of Cr(VI) was 500 mg/L, and the adsorption rate of resin to Cr was more than 95% when the initial concentration of Cr(VI) was lower than 20 mg/L. The adsorption process of Cr(VI) by the resin can be described by the Langmuir isothermal adsorption model and the pseudo second order kinetic equation. The resin has potential application prospects in the treatment of the wastewater containing chromium.