Nano-oxides with special sizes and structures can effectively fill the microcracks and pores of epoxy resin that formed by local shrinkage during the curing process. Besides, the mechanical property of epoxy coating can be significantly enhanced by intrinsic high hardness of nano-oxides, which thus are widely applied in the field of coating protection. In this paper, based on the latest research progress at home and abroad, the characteristics of nano-oxides, e.g. silica, titanium dioxide, zinc oxide, alumina oxide and ceria oxide, and their applications in epoxy coating were reviewed, including summarizing the structure and performance characteristics of various nano-oxides, comparing the different modification effects of different nano-oxides, and discussing the strengthening mechanisms of coatings in detail. Finally, the future development trend of nano-oxides in anti-corrosive coating is prospected.