Mustard gas (HD) is the most widely used chemical warfare agent that is refractory and lethal. The new generation of MOFs material MOF-808 has been studied, which has a good degradation effect. However, the current research on the degradation of HD by MOF-808 is mostly used in powder form, which is easy to agglomerate and difficult to recycle. To solve this problem, this study uses electrospun polyacrylonitrile (PAN) to fix and recover MOF-808, and validates MOF- 808@PAN has excellent degradation effect on HD. The MOF-808@PAN nanofiber material was synthesized with ZrOCl2 and trimesic acid as raw materials, trifluoroacetic acid as a regulator, and template-free based on water as a solvent. The catalyst structure was characterized by SEM, XRD, FTIR, TG and nitrogen adsorption and desorption. The experimental results show that the MOF-808@PAN nanofiber has a specific surface area of 441.5m2/g. After 20 hours of exposure to 5μL of mustard gas simulant (CEES), 83.7% of CEES has been decomposed. Provide a new solution for HD degradation.