Polyimides have been widely used in many fields as a kind of functional polymer material with unique structure. Fluorinated polyimides have attracted more and more attention with the improvement of people's requirements on the comprehensive properties of material. The introduction of fluorine into polyimide structure can improve the solubility and transmittance and reduce the moisture absorption and dielectric constant of the material. The research progress in the molecular design, synthesis and application properties of fluorinated polyimides in recent years is reviewed. It is pointed out that structural design lead to the enhanced properties. Especially, the solubility, optical properties and thermal properties of fluorinated polyimides are summarized. And the development direction of their application in flexible display panel/substrate market is prospected.