Hydrogel is generally used as medical dressing because of its high water content and 3D network. However, it is a big challenge to achieve controllable drug release from the hydrogels. In order to prepare a kind of hydrogel dressing with good biocompatibility and controllable drug release, physical crosslinking was carried out. In this study, amino acid monomer N-acryl glycine amide (NAGA) and biological fermentation product itaconic acid (IA) were used as monomers. Under UV light, the hydrogel Poly(N-acryloylglycine-itaconic acid) (P(NAGA-IA)) could be formed without addition of crosslinking agent by self-polymerization. The obtained hydrogel showed lower sol-gel transition temperature (UCST), higher water swelling (40 times) and mechanical properties (540 kPa of maximum compression modulus), and better drug loading and release. NAGA chains provided intermolecular hydrogen bonds to give better comprehensive properties of hydrogels. Moreover, IA units provided pH stimuli responsive property, which could induce drug release. Therefore, the P (NAGA-IA) hydrogel could be used as wound dressing for wound healing.