In order to discover and develop more efficient acaricides, two trifluoroethyl thioether (sulfoxide) derivatives TC-1 and TC-2 were synthesized by structural optimization with 2-(chloromethyl)-N-(2-fluoro-4-methyl-5-((2, 2, 2-trifluoroethyl)thio)phenyl)benzamide (compound Ⅶ) as lead compound. Their structures were confirmed by 1HNMR, 13CNMR and HRMS. Greenhouse acaricidal activity data showed that the mortality rates of TC-1 and TC-2 against Tetranychus cinnabarinus at 10 mg/L were 100% and 90.6%, respectively. Target compounds exhibited excellent acaricidal activity and can be used as lead compounds or candidate acaricides for further study and development.