Due to the changes in properties such as solid solution strengthening, the solid solution has a significant improvement in thermal stability and structural performance compared with a single component metal, so it has broad application prospects in catalysts. Aiming at the application of solid solution catalysts in the reaction of CO2 hydrogenation to methanol, this paper summarizes the properties and preparation methods of solid solutions, focusing on the reaction mechanism and measures to improve catalytic activity, and finds out the existing problems. The research direction of solid solution catalysts in the field of CO2 hydrogenation to methanol is prospected, and it is believed that solid solution catalysts are expected to provide a new paradigm for the research and development of catalysts in various reactions of CO2 resource utilization.