Alumina sol, acrylic acid-acrylamide co-polymer (AC-1) and hexamethylenetetramine were used to synthesize alumina spherical granules via oil-drop method, which was then used to prepare Pd/Al2O3 catalyst for the hydrogenation of alkyl-anthraquinone by wet impregnation. The structure of catalysts was characterized by N2 adsorption, XRD, TEM, and CO pulse titration and the effect of adding acrylic acid-acrylamide co-polymer (AC-1) was studied. The result showed that the addition of AC-1 did not alter the crystal structure of the catalyst, but increased specific surface area and pore size, and reduce the size of Pd particles. After using AC-1, catalytic activity in a laboratory reactor rose from 12.5 to 14.5 g/L, space-time yields in the model plant with hydrogen peroxide capacity of 10 kg/d and in the industrial plant with hydrogen peroxide capacity of 7000 t/a were improved by around 77% and 70.0% respectively. Space-time yield in the industrial plant with hydrogen peroxide capacity of 0.2 million t/a increased to 8.35 kg H2O2/ (kg CAT•d), significantly larger than that of commercial counterpart, which was less 6.50 kg H2O2/ (kg CAT•d).