Using H2Ti3O7 nanowires as precursors, yM/TiO2 catalysts（M=Fe, Co, Ni, y = 0.25%, 0.75%, 1.25%, 1.75%, 2.25%）with different metal-doped were prepared by simple ion exchange and high temperature calcination. yM/TiO2 catalysts were characterized by XRD, SEM, TEM and XPS. The results showed that the doped metal elements were evenly dispersed on the surface of the prepared TiO2 nanowire matrix. The morphology of yM/TiO2 catalysts were nanowire/nanorod. The incorporation of metal ions caused the distortion of local lattice in the TiO2 Crystal structure, resulting in the formation of more oxygen vacancies on the catalyst surface and improved the catalytic activity. The catalytic performance of yM/TiO2 in the synthesis of N-methylmorpholine (NMM) to N-methylmorpholine-N-oxide (NMMO) with H2O2 as oxidant was investigated. The results showed that when the doped metal Fe content was 1.75%, the surface defect oxygen content of the catalyst was as high as 16.86%, and the catalytic performance was the best. The yield of NMMO reached 97.5% after reaction at 35 ℃ for 3 h.