In order to discover highly effective insecticide, a meta-dicaramide compound N-[2-bromo-4-(perfluoropropane-2-yl)-6-(trifluoromethyl)phenyl]-3-[N-(cyanomethyl)benzoylamino]-2-fluorobenzamide(NC-1) was designed and synthesized by using the strategy of active pharmacophore fusion with methyl 2-fluoro-3-aminobenzoate and 2-trifluoromethylaniline as starting materials. The structure of compound NC-1 was confirmed by 1H NMR, 13C NMR and HRMS. The preliminary bioassay results in greenhouse showed that compound NC-1 exhibited excellent insecticidal activity, the mortality of compound NC-1 against Plutellaxylostella was 96.67 % at 0.05 mg/L and 93.33 % against Chilosuppressalis at 0.625 mg/L. Compound NC-1 can be used as a lead compound or a candidate insecticide for further research and development.