Ferroptosis is a newly discovered method of programmed cell death, the process of which is related to iron-dependent lipid peroxidation metabolism. In this paper, the FeⅢEGCG network structure formed by the coordination of epigallocatechin-3-gallate (EGCG) and Fe3 is used as the nanocarrier, and the ferroptosis inducer sorafenib (SRF) is loaded to prepare nanocomplexes. The nanocomplexes were characterized by particle size measurement, Zeta potential measurement and the content ratio measurement of each substance. The results of the activity evaluation showed that the nano drug containing SRF has obvious inhibitory effect on the growth of tumor cells, and the survival rate of tumor cells is about 30%. At the same time, it was found that the nanocomplex has a synergistic effect on tumor cell growth inhibition in various forms, and induction of cell ferroptosis is indeed one of the ways of action of the nanocomplex.