Hydrogen production by electrolysis of water is a hot topic in the research of green hydrogen energy, the high overpotential of the oxygen evolution reaction is the main reason for the slow kinetics of electrolysis of water. In order to improve the efficiency of hydrogen production by electrolysis of water, the amorphous transition metal boride Ni-Fe-Co-B was mainly prepared by simple liquid phase synthesis with sodium borohydride and transition metal Ni, Fe and Co salts as raw materials, using it as the oxygen evolution reaction catalyst. The materials were characterized by SEM, TEM, XRD, XPS and Electrochemical characterization. The results show that the amorphous catalytic material Ni-Fe-Co-B has been successfully synthesized, When n(Ni)∶n(Fe)∶n(Co)=1∶1∶1, the overpotential is only 299 mV and the Tafel slope is 101 mV/dec at current density of 20 mA/cm2. Under the constant voltage test of 0.47 V, Ni-Fe-Co-B has excellent stability of more than 12 h.