In recent years, the introduction of fluorine into molecules for modification had become one of the hot topics in the field of material synthesis. After the introduction of fluorine atom, charge transport properties and liquid crystal phase behavior, and ultimately improve the thermal, optical, electrical and magnetic properties of the material. Due to its high carrier mobility, the synthesis methods and properties of fluorinated discoid liquid crystals have attracted extensive attention. It had been reported that the substituted fluorine atoms in the cores, chains and bridge positions could significantly improve the liquid crystal phase behavior, thermal stability and columnar phase order. In this paper, the progress in the modification of discotic liquid crystals by fluorine atoms in recent ten years was reviewed, which proved that fluoridation was beneficial to improve the properties of liquid crystals, and further summarized the applications of discotic molecules containing fluorine in other fields. The excellent properties of discotic liquid crystals after fluorination may inspire researchers to introduce fluorine-containing materials in the fields of drug synthesis and inorganic materials.