Using diethyl fumarate and 1,2-propanediol as the basic raw materials, poly(propylene fumarate) (PPF) was successfully synthesized through a two-step reaction, the PPFand hydroxyethyl acrylate were used as monomers to thermally solidify the system material.These polymerswerecharacterized by fouriertransformation infrared spectroscopy (FTIR) and hydrogen nuclear magnetic resonance spectroscopy (1H NMR). The thermal stability, wetting properties, mechanical strength, in vitro cytotoxicity and degradation properties of the materials were tested. These results showed that the system materials had good thermal stability, specially when the mass ratio of the PPF and hydroxyethyl acrylate was1∶3. The thermal stability, and hydrophilicityof the material was better with its contact angle being53.28°～76.17°; the material had good mechanical properties, its shear strength, adhesive strength, compressive strength and three-point bending strength were 1.33～1.63 MPa, 1.86～3.18 MPa, 60.47～88.15 MPa, 18.77～20.63 MPa, respectively; the results of in vitro degradation experimentsshowed that with the increase of soaking time, the pH of the system solution tends to decrease, and the valuechanges to 0.628 from 0.093.When the mass ratio of the PPF and hydroxyethyl acrylate was 3∶1, the weight loss rate and water absorption rate can reach 11.20% and 38.27%, respectively. Finally the degradation rate of the material was relatively slow and the cytotoxicity test results showed that the cytotoxicity of the system material was slight.