The functions of moisturizing, sunscreen, anti-oxidation, inhibiting melanin and anti-aging of single component and complexes of Lonicera japonica polyphenols and ethanol extract of lingonberry were determined by weighing, dilution transmittance method, the scavenging capacities of [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH), the tyrosinase inhibitory activity and elastase inhibitory activity, m(Lonicera japonica polyphenols): m(ethanol extract of lingonberry)=4:1, 2:1, 1:1, 1:2, 1:4. The Chou-Talalay combination index (CI) was used to analyze whether there were synergistic effects between the two. The results showed that m(Lonicera japonica polyphenols): m(ethanol extract of lingonberry)=1:2 and 1:4 showed synergistic effect on moisturizing; m(Lonicera japonica polyphenols): m(ethanol extract of lingonberry)=4:1, 2:1 and 1:1 exhibited synergistic effect on anti-UVB; all five complexes showed synergistic effects on scavenging ABTS free radicals, and the CI values were 0.79±0.036, 0.83±0.041, 0.85±0.026, 0.96±0.03, 0.98±0.027, respectively; all five complexes showed synergistic effects on scavenging DPPH free radicals, and the CI values were 0.69±0.046, 0.67±0.039, 0.78±0.031, 0.89±0.018, 0.97±0.029, respectively; m(Lonicera japonica polyphenols): m(ethanol extract of lingonberry)=4:1 showed antagonistic effect on inhibiting tyrosinase, while the other complexes exhibited synergistic effect, and the CI values were 0.71±0.054, 0.68±0.04, 0.76±0.033, 0.81±0.06, respectively; m(Lonicera japonica polyphenols): m(ethanol extract of lingonberry)=1:1, 1:2 and 1:4 exhibited synergistic effect on inhibiting elastase, and the CI values were 0.84±0.053, 0.88±0.042, 0.86±0.041, respectively. The results proved that the combination of Lonicera japonica polyphenols and ethanol extract of Lingonberry had synergistic effect on skin care. Combined with the performance on five skin care functions and synergistic effect, m(Lonicera japonica polyphenols): m(ethanol extract of lingonberry)=1:1 was the optimal complex for this study.