In this paper, the traditional coprecipitation method was improved, and a new Cu-O-Al framework catalyst with high surface area (383.87 m2/g) and high dispersion (42.74%) was successfully prepared. The characterization results show that the improved preparation method can effectively increase the The large specific surface area and pore volume of the catalyst make the particles of copper species on the catalyst smaller and the dispersion degree higher, thereby showing higher catalytic activity. At the same time, due to the formation of the Cu-O-Al framework structure, the migration of copper species can be significantly inhibited, thereby improving the stability of the catalyst. In this paper, air with lower cost was used as the oxygen source, and the reaction temperature was 300 ℃ on a typical catalyst (CuAl3) and the liquid hourly space velocity was 2 h-1, the optimal conversion rate of MOP was 85.2%, and the selectivity of MOA was 55.7%. And stable operation for 32 h, and the catalyst prepared by traditional impregnation method at this space velocity has basically no catalytic activity.