The intelligent drug delivery system with multi stimulus cooperative response has important research value. In this paper, PNIPAM-co-AA microgels were synthesized using N-isopropylacrylamide (NIPAM) as monomer, acrylic acid (AA) as functional monomer by emulsion polymerization. PNIPAM-co-AA/GO composite system was obtained by ultrasonic blending of PNIPAM-co-AA and GO, which was applied to the study of drug release. The microstructure and properties of microgels and composite system were characterized by FTIR, SEM, DLS and UV-Vis. The results showed that the particle size of PNIPAM-co-AA microgels was about 458.7 nm, the Lower Critical Solution Temperature (LCST) increases to 40 ℃, showing temperature and pH sensitivity. After the introduction of GO into the PNIPAM-co-AA microgel system, the presence of GO transformed the temperature response control of the composite system into Near Infra-Red (NIR) response. The results showed that the composite system is irradiated by NIR light, and can convert NIR light energy into LCST in microgel within 3 min. After multiple cycles, the photothermal conversion performance is stable. The drug release study showed that under the conditions of NIR and pH 7.4, the cumulative release rate of 5-Fluorouracil (5-FU) within 24 hours was the highest, reaching 77.24%.