Abstract:To develop new compounds with high biological activity, a series of novel N-pyridylpyrazole-4-carboxamides containing sulfur moiety were designed and synthesized. The target compounds were identified by 1H NMR, 13C NMR, high-resolution mass spectrum (HRMS) or elemental analysis. The insecticidal activities of new compounds against oriental armyworm (Mythimna separata) were evaluated. The results of bioassays indicated that the title compounds showed moderate activities at the 200mg/L. Moreover, the fungicidal activities in vitro against five fungi at 50 mg/L indicated that some compounds exhibited promising fungicidal activities. Especially, N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin -2-yl)-3- (methylsulfanyl)-1H-pyrazole-4-carboxamide If and N-[4-chloro-2-(cyclopropylcarbamoyl)-6-methylphenyl] -1-(3-chloropyridin-2-yl)-3-(methylsulfanyl)-1H-pyrazole-4-carboxamide Ig displayed a good fungicidal activity against Alternaria solani, the inhibitory rate were 65.2% and 67.1%, respectively, which was higher than the positive control compound chlorothalonil.