A chitosan quaternary ammonium salt crosslinked amide copolymer (CC-GPPC) was prepared by aqueous copolymerization using adipic acid (AA) and diethylenetriamine (DETA) as raw materials, glycidyl methacrylate (GMA) as crosslinking monomer and hydroxypropyl trimethylammonium chloride chitosan (CC) as cationic monomer. The structure and stability of CC-GPPC were characterized by IR, SEM, TG and GPC. The effects of DETA, CC and GMA monomers dosage on the properties of CC-GPPC and the physical properties of paper after sizing were discussed. The results showed that when the content of CC was 1.0g and the molar ratio of AA:DETA:GMA is 1:1.1:0.9, the better performance of amide polyamine copolymer CC-GPPC can be prepared. At this time, the molecular weight of the polymer solution is 74520, the average particle size is 795 nm, and the dispersion index(PDI) is 0.581, it can be stably stored for more than 60 days at room temperature. when the amount of CC-GPPC is 0.6% of the total dry pulp, the dry and wet tensile indexes of paper were 52.99N.m/g and 15.21N.m/g, respectively. Compared with base paper, the dry and wet tensile indexes of paper increased by 29.8% and 63.4% respectively, paper wet-strength performance significantly improved, compared with commercial PAE wet strength resin, chlorine free and superior performance, paper wet resistance to tensile index increased 10.9%, CC-GPPC is a green paper wet-strength agent.