Metal organic frameworks (MOFs) have excellent characteristics such as large specific surface area, good designability and biocompatibility, which can be used as ideal carriers of immobilized enzymes to improve the stability and catalytic performance of free enzymes. Many enzyme/MOFs composites show much better catalytic performance than free enzymes. Enzyme/MOFs composites have been widely reported to be used in biosensing, detection, catalysis and other fields, becoming an environmentally friendly substitute for traditional catalysts. This paper summarized three immobilization methods of enzyme on MOFs (Surface immobilization, Pore encapsulation and In-situ synthesis), and emphatically introduced four factors influencing the catalytic performance of enzyme/MOFs composites and the modulation methods. Finally, the application of enzyme/MOFs composites in catalysis is summarized and the future of enzyme immobilization is anticipated.