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Regulation of catalytic performance and application of enzyme / MOFs composites
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Affiliation:

1.College of Textile Science and Engineering,Tiangong University,Tianjin;2.College of Textile Science and Engineering, Tiangong University

Clc Number:

Q814.2；TQ426.97

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    Abstract:

    Metal organic frameworks (MOFs) have excellent characteristics such as large specific surface area, good designability and biocompatibility, which can be used as ideal carriers of immobilized enzymes to improve the stability and catalytic performance of free enzymes. Many enzyme/MOFs composites show much better catalytic performance than free enzymes. Enzyme/MOFs composites have been widely reported to be used in biosensing, detection, catalysis and other fields, becoming an environmentally friendly substitute for traditional catalysts. This paper summarized three immobilization methods of enzyme on MOFs (Surface immobilization, Pore encapsulation and In-situ synthesis), and emphatically introduced four factors influencing the catalytic performance of enzyme/MOFs composites and the modulation methods. Finally, the application of enzyme/MOFs composites in catalysis is summarized and the future of enzyme immobilization is anticipated.

    Reference
    [1] Yushkova E D, Nazarova E A, Matyuhina A V, et al. Application of Immobilized Enzymes in Food Industry[J]. Journal of Agricultural and Food Chemistry. 2019, 67(42): 11553-11567.
    [2] Da Silva R R. Agricultural Enzymes, Phosphatases, Peptidases, and Sulfatases and the Expectations for Sustainable Agriculture[J]. Journal of Agricultural and Food Chemistry. 2019, 67(16): 4395-4396.
    [3] Liu J, Ma R, Shi Y. An immobilization enzyme for screening lipase inhibitors from Tibetan medicines[J]. Journal of Chromatography A. 2020, 1615: 460711.
    [4] Torres Castillo N E, Melchor-Martínez E M, Ochoa Sierra J S, et al. Enzyme mimics in-focus: Redefining the catalytic attributes of artificial enzymes for renewable energy production[J]. International Journal of Biological Macromolecules. 2021, 179: 80-89.
    [5] Hu Y, Dai L, Liu D, et al. Progress prospect of metal-organic frameworks (MOFs) for enzyme immobilization (enzyme/MOFs)[J]. Renewable and Sustainable Energy Reviews. 2018, 91: 793-801.
    [6] Yaashikaa P R, Devi M K, Kumar P S. Advances in the application of immobilized enzyme for the remediation of hazardous pollutant: A review[J]. Chemosphere. 2022, 299: 134390.
    [7] Zou B, Wang P, Xia J, et al. Enzyme Biosensors Systems Based on Co-Modification of Carbon Nanotubes and Enzyme for Detection of Glucose in Food[J]. Journal of the Electrochemical Society. 2021, 168(6): 65501.
    [8] Cho Y K, Bailey J E. Immobilization of enzymes on activated carbon: Selection and preparation of the carbon support[J]. Biotechnology and Bioengineering. 1979, 21(3): 461-476.
    [9] Kawachi Y, Kugimiya S, Nakamura H, et al. Enzyme encapsulation in silica gel prepared by polylysine and its catalytic activity[J]. Applied Surface Science. 2014, 314: 64-70.
    [10] Basu S, Omadjela O, Gaddes D, et al. Cellulose Microfibril Formation by Surface-Tethered Cellulose Synthase Enzymes[J]. ACS Nano. 2016, 10(2): 1896-1907.
    [11] Long J R, Yaghi O M. The pervasive chemistry of metal–organic frameworks[J]. Chemical Society Reviews. 2009, 38(5): 1213.
    [12] Zhou H, Long J R, Yaghi O M. Introduction to Metal–Organic Frameworks[J]. Chemical Reviews. 2012, 112(2): 673-674.
    [13] Si J, Zhang S, Liu X, et al. Flower-Shaped Ni/Co MOF with the Highest Adsorption Capacity for Reactive Dyes[J]. Langmuir. 2022, 38(19): 6004-6012.
    [14] Pisklak T J, Macías M, Coutinho D H, et al. Hybrid materials for immobilization of MP-11 catalyst[J]. Topics in Catalysis. 2006, 38(4): 269-278.
    [15] Mehta J, Bhardwaj N, Bhardwaj S K, et al. Recent advances in enzyme immobilization techniques: Metal-organic frameworks as novel substrates[J]. Coordination Chemistry Reviews. 2016, 322: 30-40.
    [16] Gkaniatsou E, Sicard C, Ricoux R, et al. Metal–organic frameworks: a novel host platform for enzymatic catalysis and detection[J]. Materials Horizons. 2017, 4(1): 55-63.
    [17] Li R, Liu S, Zhou X, et al. Efficient immobilization of catalase on mesoporous MIL-101 (Cr) and its catalytic activity assay[J]. Enzyme and Microbial Technology. 2022, 156: 110005.
    [18] Wang B, Zhou J, Zhang X, et al. Covalently immobilize crude d-amino acid transaminase onto UiO-66-NH2 surface for d-Ala biosynthesis[J]. International Journal of Biological Macromolecules. 2021, 175: 451-458.
    [19] Samui A, Chowdhuri A R, Mahto T K, et al. Fabrication of a magnetic nanoparticle embedded NH2 -MIL-88B MOF hybrid for highly efficient covalent immobilization of lipase[J]. RSC Advances. 2016, 6(71): 66385-66393.
    [20] Zhai R, Yuan Y, Jiao F, et al. Facile synthesis of magnetic metal organic frameworks for highly efficient proteolytic digestion used in mass spectrometry-based proteomics[J]. Analytica Chimica Acta. 2017, 994: 19-28.
    [21] Tan W, Wei T, Huo J, et al. Electrostatic Interaction-Induced Formation of Enzyme-on-MOF as Chemo-Biocatalyst for Cascade Reaction with Unexpectedly Acid-Stable Catalytic Performance[J]. ACS applied materials interfaces. 2019, 11(40): 36782-36788.
    [22] Chowdhury R, Stromer B, Pokharel B, et al. Control of Enzyme–Solid Interactions via Chemical Modification[J]. Langmuir. 2012, 28(32): 11881-11889.
    [23] Jung S, Kim Y, Kim S, et al. Bio-functionalization of metal–organic frameworks by covalent protein conjugation[J]. Chemical Communications. 2011, 47(10): 2904.
    [24] Xu M, Yuan S, Chen X, et al. Two-Dimensional Metal–Organic Framework Nanosheets as an Enzyme Inhibitor: Modulation of the α-Chymotrypsin Activity[J]. Journal of the American Chemical Society. 2017, 139(24): 8312-8319.
    [25] Suksatan W, Kazemzadeh P, Afzali D, et al. A controllable study on ultrasound assisted synthesis of a novel Ni/Zn based hybrid MOF nanostructures for Dextranase immobilization[J]. Inorganic Chemistry Communications. 2022, 139: 109410.
    [26] Maddigan N K, Tarzia A, Huang D M, et al. Protein surface functionalisation as a general strategy for facilitating biomimetic mineralisation of ZIF-8?[J]. Chemical Science. 2018.
    [27] Xu M, Meng S, Liang H, et al. A metal–organic framework with tunable exposed facets as a high-affinity artificial receptor for enzyme inhibition[J]. Inorganic Chemistry Frontiers. 2020, 7(19): 3687-3694.
    [28] Chen Y, Han S, Li X, et al. Why Does Enzyme Not Leach from Metal–Organic Frameworks (MOFs)? Unveiling the Interactions between an Enzyme Molecule and a MOF[J]. Inorganic Chemistry. 2014, 53(19): 10006-10008.
    [29] Horcajada P, Gref R, Baati T, et al. Metal-organic frameworks in biomedicine.[J]. Chemical Reviews. 2012.
    [30] Li P, Moon S, Guelta M A, et al. Nanosizing a Metal–Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis[J]. ACS Nano. 2016.
    [31] Lykourinou V, Chen Y, Wang X, et al. Immobilization of MP-11 into a Mesoporous Metal–Organic Framework, MP-11@mesoMOF: A New Platform for Enzymatic Catalysis[J]. Journal of the American Chemical Society. 2011, 133(27): 10382-10385.
    [32] Zhang X, Tu R, Lu Z, et al. Hierarchical mesoporous metal–organic frameworks encapsulated enzymes: Progress and perspective[J]. Coordination Chemistry Reviews. 2021, 443: 214032.
    [33] Lian X, Fang Y, Joseph E, et al. Enzyme–MOF (metal–organic framework) composites[J]. Chemical Society Reviews. 2017, 46(11): 3386-3401.
    [34] Liu X, Qi W, Wang Y, et al. A facile strategy for enzyme immobilization with highly stable hierarchically porous metal–organic frameworks[J]. Nanoscale. 2017, 9(44): 17561-17570.
    [35] Chen W, Yang W, Lu Y, et al. Encapsulation of enzyme into mesoporous cages of metal–organic frameworks for the development of highly stable electrochemical biosensors[J]. Analytical Methods. 2017, 9(21): 3213-3220.
    [36] Gao X, Ding Y, Sheng Y, et al. Enzyme Immobilization in MOF‐derived Porous NiO with Hierarchical Structure: An Efficient and Stable Enzymatic Reactor[J]. ChemCatChem. 2019, 11(12): 2828-2836.
    [37] Wu J, Wang Y, Han J, et al. A method of preparing mesoporous Zr-based MOF and application in enhancing immobilization of cellulase on carrier surface[J]. Biochemical Engineering Journal. 2022, 180: 108342.
    [38] Yang P, Mao F, Li Y, et al. Hierarchical Porous Zr-Based MOFs Synthesized by a Facile Monocarboxylic Acid Etching Strategy[J]. Chemistry - A European Journal. 2018, 24(12): 2962-2970.
    [39] Zhao Z, Huang Y, Liu W, et al. Immobilized Glucose Oxidase on Boronic Acid-Functionalized Hierarchically Porous MOF as an Integrated Nanozyme for One-Step Glucose Detection[J]. ACS Sustainable Chemistry Engineering. 2020, 8(11): 4481-4488.
    [40] Cao Y, Wu Z, Wang T, et al. Immobilization of Bacillus subtilis lipase on a Cu-BTC based hierarchically porous metal–organic framework material: a biocatalyst for esterification[J]. Dalton Transactions. 2016, 45(16): 6998-7003.
    [41] Velásquez-Hernández M D J, Astria E, Winkler S, et al. Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans[J]. Chemical Science. 2020, 11(39): 10835-10843.
    [42] Wang S, Chen Y, Wang S, et al. DNA-Functionalized Metal–Organic Framework Nanoparticles for Intracellular Delivery of Proteins[J]. Journal of the American Chemical Society. 2019, 141(6): 2215-2219.
    [43] Lyu F, Zhang Y, Zare R N, et al. One-Pot Synthesis of Protein-Embedded Metal–Organic Frameworks with Enhanced Biological Activities[J]. Nano Letters. 2014, 14(10): 5761-5765.
    [44] Wang L, Zhi W, Wan J, et al. Recyclable β-Glucosidase by One-Pot Encapsulation with Cu-MOFs for Enhanced Hydrolysis of Cellulose to Glucose[J]. ACS Sustainable Chemistry Engineering. 2019, 7(3): 3339-3348.
    [45] Nadar S S, Vaidya L, Rathod V K. Enzyme embedded metal organic framework (enzyme–MOF): De novo approaches for immobilization[J]. International Journal of Biological Macromolecules. 2020, 149: 861-876.
    [46] Liao F, Lo W, Hsu Y, et al. Shielding against Unfolding by Embedding Enzymes in Metal–Organic Frameworks via a de Novo Approach[J]. Journal of the American Chemical Society. 2017, 139(19): 6530-6533.
    [47] Liang K, Coghlan C J, Bell S G, et al. Enzyme encapsulation in zeolitic imidazolate frameworks: a comparison between controlled co-precipitation and biomimetic mineralisation[J]. Chemical Communications. 2016, 52(3): 473-476.
    [48] Wang Y, Hou C, Zhang Y, et al. Preparation of graphene nano-sheet bonded PDA/MOF microcapsules with immobilized glucose oxidase as a mimetic multi-enzyme system for electrochemical sensing of glucose[J]. Journal of Materials Chemistry B. 2016, 4(21): 3695-3702.
    [49] Chen S, Lo W, Huang Y, et al. Probing Interactions between Metal–Organic Frameworks and Freestanding Enzymes in a Hollow Structure[J]. Nano Letters. 2020, 20(9): 6630-6635.
    [50] Zhang S, Deng Q, Li Y, et al. Novel amphiphilic polyvinylpyrrolidone functionalized silicone particles as carrier for low-cost lipase immobilization[J]. Royal Society open science. 2018, 5(6): 172368.
    [51] Hsu P, Chang C, Wang T, et al. Rapid Fabrication of Biocomposites by Encapsulating Enzymes into Zn-MOF-74 via a Mild Water-Based Approach[J]. ACS Applied Materials Interfaces. 2021, 13(44): 52014-52022.
    [52] Yan M, Ge J, Liu Z, et al. Encapsulation of Single Enzyme in Nanogel with Enhanced Biocatalytic Activity and Stability[J]. Journal of the American Chemical Society. 2006, 128(34): 11008-11009.
    [53] Hoarau M, Badieyan S, Marsh E N G. Immobilized enzymes: understanding enzyme – surface interactions at the molecular level[J]. Organic Biomolecular Chemistry. 2017, 15(45): 9539-9551.
    [54] Ma X, Sui H, Yu Q, et al. Silica Capsules Templated from Metal–Organic Frameworks for Enzyme Immobilization and Catalysis[J]. Langmuir. 2021, 37(10): 3166-3172.
    [55] Motamedi N, Barani M, Lohrasbi-Nejad A, et al. Enhancement of Thermostability of Aspergillus flavus Urate Oxidase by Immobilization on the Ni-Based Magnetic Metal–Organic Framework[J]. Nanomaterials. 2021, 11(7): 1759.
    [56] Wang J, Zhao G, Yu F. Facile preparation of Fe3O4@MOF core-shell microspheres for lipase immobilization[J]. Journal of the Taiwan Institute of Chemical Engineers. 2016, 69: 139-145.
    [57] Koo J, Hwang I, Yu X, et al. Hollowing out MOFs: hierarchical micro- and mesoporous MOFs with tailorable porosity via selective acid etching[J]. Chemical Science. 2017, 8(10): 6799-6803.
    [58] Cheng K, Svec F, Lv Y, et al. Hierarchical Micro‐ and Mesoporous Zn‐Based Metal–Organic Frameworks Templated by Hydrogels: Their Use for Enzyme Immobilization and Catalysis of Knoevenagel Reaction[J]. Small. 2019, 15(44): 1902927.
    [59] Li P, Moon S, Guelta M A, et al. Encapsulation of a Nerve Agent Detoxifying Enzyme by a Mesoporous Zirconium Metal–Organic Framework Engenders Thermal and Long-Term Stability[J]. Journal of the American Chemical Society. 2016, 138(26): 8052-8055.
    [60] Dutta S, Kumari N, Dubbu S, et al. Highly Mesoporous Metal‐Organic Frameworks as Synergistic Multimodal Catalytic Platforms for Divergent Cascade Reactions[J]. Angewandte Chemie International Edition. 2020, 59(9): 3416-3422.
    [61] Navarro-Sánchez J, Almora-Barrios N, Lerma-Berlanga B, et al. Translocation of enzymes into a mesoporous MOF for enhanced catalytic activity under extreme conditions?[J]. Chemical Science. 2019.
    [62] Man T, Xu C, Liu X, et al. Hierarchically encapsulating enzymes with multi-shelled metal-organic frameworks for tandem biocatalytic reactions[J]. Nature Communications. 2022, 13(1).
    [63] Ma J, Chen G, Bai W, et al. Amplified Electrochemical Hydrogen Peroxide Sensing Based on Cu-Porphyrin Metal–Organic Framework Nanofilm and G-Quadruplex-Hemin DNAzyme[J]. ACS Applied Materials Interfaces. 2020, 12(52): 58105-58112.
    [64] van Oers M C M, Rutjes F P J T, van Hest J C M. Cascade reactions in nanoreactors.[J]. Current Opinion in Biotechnology. 2014.
    [65] Feng D, Gu Z, Li J, et al. Zirconium-Metalloporphyrin PCN-222: Mesoporous Metal–Organic Frameworks with Ultrahigh Stability as Biomimetic Catalysts?[J]. Angewandte Chemie. 2012.
    [66] Ye R, Zhao J, Wickemeyer B B, et al. Foundations and strategies of the construction of hybrid catalysts for optimized performances[J]. Nature Catalysis. 2018, 1(5): 318-325.
    [67] Zhao M, Li Y, Ma X, et al. Adsorption of cholesterol oxidase and entrapment of horseradish peroxidase in metal-organic frameworks for the colorimetric biosensing of cholesterol[J]. Talanta. 2019.
    [68] Wang Q, Zhang X, Huang L, et al. GOx@ZIF-8(NiPd) Nanoflower: An Artificial Enzyme System for Tandem Catalysis[J]. Angewandte Chemie International Edition. 2017, 56(50): 16082-16085.
    [69] Liu X, Qi W, Wang Y, et al. Rational Design of Mimic Multienzyme Systems in Hierarchically Porous Biomimetic Metal–Organic Frameworks[J]. ACS Applied Materials Interfaces. 2018, 10(39): 33407-33415.
    [70] Shen H, Shi H, Yang Y, et al. Highly efficient synergistic biocatalysis driven by stably loaded enzymes within hierarchically porous iron/cobalt metal–organic framework via biomimetic mineralization[J]. Journal of Materials Chemistry B. 2022.
    [71] Huang S, Chen G, Ye N, et al. Iron-Mineralization-Induced Mesoporous Metal–Organic Frameworks Enable High-Efficiency Synergistic Catalysis of Natural/Nanomimic Enzymes[J]. ACS Applied Materials Interfaces. 2020, 12(51): 57343-57351.
    [72] Han L, Zheng D, Chen S, et al. A Highly Solvent-Stable Metal-Organic Framework Nanosheet: Morphology Control, Exfoliation, and Luminescent Property.[J]. Small. 2018.
    [73] Pathak A, Shen J, Usman M, et al. Integration of a (–Cu–S–) n plane in a metal–organic framework affords high electrical conductivity[J]. Nature Communications. 2019.
    [74] Xie L S, Skorupskii G, Dinc? M. Electrically Conductive Metal-Organic Frameworks.[J]. Chemical Reviews. 2020.
    [75] Dhakshinamoorthy A, Asiri A M, Garcia H. 2D Metal-Organic Frameworks as Multifunctional Materials in Heterogeneous Catalysis and Electro/Photocatalysis.[J]. Advanced Materials. 2019.
    [76] Ma J, Yuan J, Xu Y, et al. Ultrasensitive electrochemical determination of bisphenol A in food samples based on a strategy for activity enhancement of enzyme: Layer-by-layer self-assembly of tyrosinase between two-dimensional porphyrin metal–organic framework nanofilms[J]. Chemical Engineering Journal. 2022, 446: 137001.
    [77] Wang J, Hu C, Wang Y, et al. Chemiluminescent Two-Dimensional Metal–Organic Framework with Multiple Metal Catalytic Centers and Its Peroxidase-like Activity for Sensing of Small Molecules[J]. ACS Applied Materials Interfaces. 2022, 14(2): 3156-3164.
    [78] Zhong X, Xia H, Huang W, et al. Biomimetic metal-organic frameworks mediated hybrid multi-enzyme mimic for tandem catalysis[J]. Chemical Engineering Journal. 2020, 381: 122758.
    [79] Ning D, Liu Q, Wang Q, et al. Luminescent MOF nanosheets for enzyme assisted detection of H2O2 and glucose and activity assay of glucose oxidase[J]. Sensors and Actuators B: Chemical. 2019, 282: 443-448.
    [80] Li S, Zhai X, Zhang C, et al. Enzyme immobilization in highly ordered macro–microporous metal–organic frameworks for rapid biodegradation of hazardous dyes[J]. Inorganic Chemistry Frontiers. 2020, 7(17): 3146-3153.
    [81] Patra S, Hidalgo Crespo T, Permyakova A, et al. Design of metal organic framework–enzyme based bioelectrodes as a novel and highly sensitive biosensing platform[J]. Journal of Materials Chemistry B. 2015, 3(46): 8983-8992.
    [82] Ma W, Jiang Q, Yu P, et al. Zeolitic Imidazolate Framework-Based Electrochemical Biosensor for in Vivo Electrochemical Measurements[J]. Analytical Chemistry. 2013, 85(15): 7550-7557.
    [83] Hassanzadeh J, Khataee A, Eskandari H. Encapsulated cholesterol oxidase in metal-organic framework and biomimetic Ag nanocluster decorated MoS2 nanosheets for sensitive detection of cholesterol[J]. Sensors and Actuators B: Chemical. 2018, 259: 402-410.
    [84] Pavadai R, Perumal P. An innovative trimetallic-MOF mediated catalytic cleavage activity of FAM tagged Ag10/T-rich DNAzyme as an ultra-sensitive and selective fluorescent biosensor for subsequent recognition of Ag+ and Hg2+ ions[J]. Journal of Photochemistry and Photobiology A: Chemistry. 2022, 429: 113901.
    [85] Feng D, Liu T, Su J, et al. Stable metal-organic frameworks containing single-molecule traps for enzyme encapsulation[J]. Nature Communications. 2015, 6(1).
    [86] Lian X, Chen Y, Liu T, et al. Coupling two enzymes into a tandem nanoreactor utilizing a hierarchically structured MOF[J]. Chemical Science. 2016, 7(12): 6969-6973.
    [87] Chen Y, Lykourinou V, Hoang T, et al. Size-Selective Biocatalysis of Myoglobin Immobilized into a Mesoporous Metal–Organic Framework with Hierarchical Pore Sizes[J]. Inorganic Chemistry. 2012, 51(17): 9156-9158.
    [88] Liu W, Lo S, Singco B, et al. Novel trypsin–FITC@MOF bioreactor efficiently catalyzes protein digestion[J]. Journal of Materials Chemistry B. 2013, 1(7): 928.
    [89] Shieh F, Wang S, Yen C, et al. Imparting Functionality to Biocatalysts via Embedding Enzymes into Nanoporous Materials by ade Novo Approach: Size-Selective Sheltering of Catalase in Metal–Organic Framework Microcrystals[J]. Journal of the American Chemical Society. 2015, 137(13): 4276-4279.
    [90] Ma J, Yuan J, Xu Y, et al. Ultrasensitive electrochemical determination of bisphenol A in food samples based on a strategy for activity enhancement of enzyme: Layer-by-layer self-assembly of tyrosinase between two-dimensional porphyrin metal–organic framework nanofilms[J]. Chemical Engineering Journal. 2022, 446: 137001.
    [91] Liu Y, Liu Y, Gu L, et al. Modulating the biofunctionality of enzyme-MOF nanobiocatalyst through structure-switching aptamer for continuous degradation of BPA[J]. Colloids and Surfaces B: Biointerfaces. 2021, 208: 112099.
    [92] Pisklak T J, Macías M, Coutinho D H, et al. Hybrid materials for immobilization of MP-11 catalyst[J]. Topics in Catalysis. 2006, 38(4): 269-278.
    [93] Ou J, Yuan X, Liu Y, et al. Lipase from pseudomonas cepacia immobilized into ZIF-8 as bio-catalyst for enantioselective hydrolysis and transesterification[J]. Process Biochemistry. 2021, 102: 132-140.
    [94] Tülek A, Y?ld?r?m D, Ayd?n D, et al. Highly-stable Madurella mycetomatis laccase immobilized in silica-coated ZIF-8 nanocomposites for environmentally friendly cotton bleaching process[J]. Colloids and Surfaces B: Biointerfaces. 2021, 202: 111672.
    [95] Cheng X, Zhou J, Chen J, et al. One-step synthesis of thermally stable artificial multienzyme cascade system for efficient enzymatic electrochemical detection[J]. Nano Research. 2019, 12(12): 3031-3036.
    [96] Yang Y, Li G, Wu D, et al. Recent advances on toxicity and determination methods of mycotoxins in foodstuffs[J]. Trends in Food Science Technology. 2020, 96: 233-252.
    [97] Selvolini G, Lettieri M, Tassoni L, et al. Electrochemical enzyme-linked oligonucleotide array for aflatoxin B1 detection[J]. Talanta. 2019, 203: 49-57.
    [98] Kempahanumakkagari S, Kumar V, Samaddar P, et al. Biomolecule-embedded metal-organic frameworks as an innovative sensing platform[J]. Biotechnology Advances. 2018, 36(2): 467-481.
    [99] Gu C, Bai L, Pu L, et al. Highly sensitive and stable self-powered biosensing for exosomes based on dual metal-organic frameworks nanocarriers[J]. Biosensors and Bioelectronics. 2021, 176: 112907.
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  • Received:August 11,2022
  • Revised:September 26,2022
  • Adopted:October 11,2022
  • Online: June 12,2023
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