Abstract: Using p-chlorobenzyl chloride as raw material, Friedel-Crafts acylation of anisole and p-chlorobenzoyl chloride was catalyzed by FeCl3, followed by hydrolysis to produce 4-chloro-4 '- hydroxybenzophenone, which reacted with acetone and chloroform by condensation to obtain fenofibrate acid. And then fenofibrate was synthesized by esterification with fenofibrate acid and isopropanol and further purification to prepare fenofibrate crystals. The structure of the product was characterized by MS, FTIR, X-ray diffraction, 1HNMR and 13CNMR. The crystal structure of fenofibrate was analyzed by X-ray crystal structure analysis. The effects of feed rate, reaction temperature and refining solvent on the yield were investigated. The optimum conditions for the synthesis of 4-chloro-4'- methoxy benzophenone are as follows: n(anisole):n(FeCl3):n(4-chlorobenzoyl chloride)=4.0:0.0125:1.0, acylation under 145~155 ℃ for 6h. The optimized conditions for synthesis of fenofibrate acid were as follows: n(CHCl3):n(4-chloro-4'-hydroxybenzophenone)=2.5:1.0, and crystallization with toluene at 10 ℃. The optimized conditions for synthesis of fenofibrate were as follows: n(fenofibrate acid):n(isopropyl alcohol):n(H2SO4)=1.0:3.0:2.0, purification with isopropyl alcohol to obtain crystals. The total yield and content of fenofibrate were 56.17% and 99.93%, respectively.