In order to endow the leather with superior antibacterial behavior, metal-organic frameworks was synthesized by using CA-CPL as the template. Subsequently, CA-CPL@ZIF-8 was applied to leather finishing. The results of XRD, SEM and TEM showed that the CA-CPL@ZIF-8 with complete crystal structure was successfully grown by turning the size of the template. The results illustrated that antibacterial effect on E. coli and S. aureus of leather increased with the increase of CA-CPL@ZIF-8 content (when the dosage was 0.8%, the inhibition zone of S. aureus was 4 mm).