Long-chain alkyl-modified nanoparticles C18-NH2/570@SiO2 were synthesized by octadecylamine (C18-NH2), ethyl orthosilicate (TEOS) and γ-methacryloyloxypropyltrimethoxysilane (KH-570) by layer-by-layer assembly method, and introduced into silicone-modified epoxy resin to obtain a superhydrophobic epoxy resin coating C18-NH2@SiO2/DE51 with excellent friction resistance. FT-IR, XRD, XPS, TEM, AFM, etc. were used to characterize the structure of nanoparticles and the film-forming morphology of coatings. The results showed that the long-chain alkyl nanoparticles were successfully introduced into the polymer segment, and the surface roughness was significantly improved after coating C18-NH2/570@SiO2. Through contact angle, light transmittance, self-cleaning, acid and alkali resistance and friction resistance tests, it is shown that when the mass fraction of nanoparticle spraying is 0.8%, the contact angle of the modified epoxy resin coating can reach 150.6±0.6°, and the rolling angle can reach 7.8±0.4°, the light transmittance reaches 91.98%, and it has good self-cleaning, acid and alkali resistance and friction resistance, and the friction number can reach more than 1500 times.