Metal-organic frameworks (MOFs) materials are widely used in various research fields due to their large specific surface area, high porosity, easy adjustment of pores and easy functionalization. However, the chemical stability and hydrothermal stability of most MOFs are poor, which greatly limits the application of MOFs. Zirconium-based MOFs material UiO-66 has attracted much attention due to its skeleton collapse temperature higher than 500 ℃, withstands 1.0 MPa mechanical pressure and has ultra-high stability. This paper systematically introduces the research progress of various synthesis methods of UiO-66, and it is believed that the dry gel conversion method has the advantages of high product yield, small reaction volume and continuous production. The effects of organic ligands, metal nodes and doping on the structure of UiO-66 were introduced in detail. The research results show that the modification of UiO-66 structure can further improve its performance. The application of UiO-66 in catalysis, gas storage and separation is summarized. The future development direction of UiO-66 is also prospected.