7-methoxytetralone(Ⅱ)was selected as staring material, condensation with cyanoacetic acid catalyzed by heptanoic acid and benzylamine to obtain (7-methoxy-3,4-dihydro-1-naphthyl)acetonitrile (III).The aromatization-reduction“one-pot” preparation of (7-methoxy-1-naphthyl)ethylamine(Ⅴ) was performed by aromatization of Ⅲ using allyl acrylate(Ⅶ) as hydrogen acceptor under 5%Pd/C(5%Pd mass fraction) to obtain (7-methoxy-1-naphthyl)acetonitrile(Ⅳ),followed by transfer hydrogenation using ammonium formate as the hydrogen donor. The optimized conditions were: aromatization, the amount of 5%Pd/C , n(Ⅲ)∶n(Ⅶ)=1.0∶1.1, and the reaction time was 4.0 h. reduction reaction, n(Ⅲ)∶n(HCO2NH4 )=1.0∶4.0, the reaction temperature was 70 °C, the reaction time was 2.0 h. V reacts with hydrochloric acid to obtain Ⅵ, and the reaction of VI with acetyl chloride obtain agomelatine (I) in 64.70% total yield. The product and intermediates were characterized by 1HNMR, 13CNMR, MS, and FTIR .The process was scaled up on a kilogram scale with an overall yield of 60.70% and a purity of 99.91%.