N,O-二-(4,6-dichloro-1,3,5-triazinyl)-glucosamine (CG) was synthesized from cyanuric chloride (TCT) and glucosamine. The structure of the synthesized product was characterized by FTIR and _¹HNMR. And it was used in the leather tanning experiment. Taking the pickled sheepskin as the material, the proper tanning process conditions were determined by single factor experiment: the dosage of CG tanning agent was 7.5% (based on the mass of the limed skin, the same below), and the tanning process was carried out in a step temperature control mode of 30, 40, and 45℃. The tanning time was 1, 1.5, and 2h, respectively; the pH of the bath solution was finally maintained at 6.0-6.5 by basification. The experimental results showed that the shrinkage temperature of the CG tanned crust leather can reach 78.9℃, the leather surface was white and delicate, and the body and bones were soft. This tanning agent is a new organic synthetic tanning agent with good tanning effect and application prospect.