The design and fabrication of bio-inspired bionic functional surfaces has become an important and fascinating research topic with a wide range of applications in daily life, industry and agriculture in recent years. Benefitting from its high flexibility, low surface energy and chemical stability, polydimethylsiloxane (PDMS) is widely used as a functional modification of bionic surfaces. This article reviews the preparation methods of PDMS-based biomimetic surfaces and their research progress in protective fields such as anti-corrosion, anti-icing, anti-biofouling and optical. Furthermore, the existing issues and development trends are summarized and prospected.