Porphyrinoid-based metal organic framework (MOF) is featured with a crystal structure formed by the coordinating self-assembly between metal or metal clusters and porphyrin ligand or porphyrinoid family compounds. It combines the good photophysical properties and biocompatibility of porphyrinoid molecules, bearing a periodic and controllable structure, which can be potentially used in the field of photochemistry and biological medicine. In particular, the excellent performance of porphyrinoid molecules in the porphyrinoid MOFs can be remained which can thus play a role in killing harmful cells in human bodies via the photo-assisted medical treatment including photokinetic and photothermal therapies. In this paper, we reviewed the recent development of porphyrinoid-based MOFs and their applications in the biomedical field including anti-tumor and anti-bacterial treatments. We mainly focused on the performance improvement of porphyrinoid-based MOF type photosensitizers, compared to that of porphyrinoid molecules, and the diverse functions derived from the different type of porphyrinoid MOFs. The development potentials of porphyrinoid MOFs were also proposed.