In order to improve the antifouling performance of Polyethersulfone (PES) membrane, SMANa/PES membranes were prepared by non-solvent induced phase separation (NIPS) method with the styrene maleic anhydride copolymer (SMANa) as additives. Afterwards, Polypyrrole (PPy) conductive layer was fabricated on SMANa/PES membranes by in situ chemical polymerization from the vapor phase with FeCl3 as the oxidant. A series of PPy/SMANa/PES conductive composite membranes were prepared by systemically investigated the oxidant concentration, time and temperature of polymerization on the performance of the membrane. The PPy/SMANa/PES conductive composite membranes obtained were characterized by FTIR, SEM and contact angle tester for structure and morphology analyses, and evaluated for water flux and antifouling performance in ultrafiltration. The results showed that, under the temperature of 30 ℃, with the concentration of FeCl3 is 0.8 mol/L, and time of polymerization is 5min, the resulting membrane had an outstanding water flux of 409 L/(m2·h) with pressure of 0.1 MPa, which is 83.75% percent of SMANa/PES membranes. After ultrasonic?irrigation, the flux recovery ratio (FRR) of the resulting membrane reach up to 86.57%, improved by 16.57% compared with SMANa/PES membranes.