Low surface energy coatings have attracted wide attention due to their excellent anti-fouling and self-cleaning abilities. However, existing coatings are prone to degradation by microorganisms such as bacteria and fungi, leading to a decrease in their anti-fouling effectiveness. Therefore, the construction of anti-fouling and antibacterial coatings is of significant importance. Based on the electrophoretic deposition process, depositing vinyl silicone oil modified polyacrylate and curing agent onto conductive substrates. After further loaded with nano silver antibacterial agents, the coatings were crosslinking curing, resulting in coatings with both anti-bacterial adhesion and bactericidal functions. The morphology and structure of the coatings were systematically characterized using Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and scanning electron microscopy (SEM). The results showed that the coating surface had excellent oil and dirt resistance, as well as the ability to resist bacteria and blood adhesion, The Anti-bacterial adhesion rate of the coating against E. coli and S.aureus exceeds 99.9%. Even after exposure to extreme conditions such as strong acid, strong alkali, and 3000 cycles of friction, the coating surface still has excellent anti-liquid adhesion effect.