A method for preparing a racemate of finerenone
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1.School of Chemistry and Chemical Engineering, Nanjing University;2.Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University

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O621.3

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    Abstract:

    Using 4-cyano-3-methoxybenzaldehyde and tert-butyl acetoacetate as raw materials, finerenone racemes were obtained through condensation, cyclization, oxyalkylation, hydrolysis and ammonolysis, which broke through the difficulty of hydrolysis of conventional esters. A series of optimization of reaction conditions were carried out, and the finerenone racemes were obtained with a total yield of 33.5%. The results showed that the reaction conditions were mild and the yield was high, which provided a reasonable route for the synthesis of finerenone raw materials. The structure of the product was determined by 1 HNMR, 13CNMR and HRMS.

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History
  • Received:October 12,2023
  • Revised:December 23,2023
  • Adopted:December 11,2023
  • Online: November 08,2024
  • Published:
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